ポータブル角質水分計　MoistureMeter SC Compact　

アーティファクト・フリーの角質水分量測定

皮膚表面（角質）の水分量を、導電率に関係ない誘電率だけを測定。測定される水分量は電解質等による影響がありません。また1測定につき400回のスキャンを行いその結果を平均化するため、より安定した正確な測定結果が得られます。
 
■測定中の肌への圧を確認できるステップバーをLEDに表示
■測定面は直径11mm程度
■ソフトで測定結果、測定圧を表示・記録
■測定データをワイヤレスで専用ソフトに転送、連携して統合測定システムを構築
■ワイヤレスをオフにして本体表示でスタンドアローンの水分計としての使用も可能
■軽さ140ｇと小型軽量、持ち運びが簡単

１）化粧品産業用研究機器　２）国内技適済みワイヤレスモデム内蔵

アプリケーション

• 吸水能、水分保持能の指標
• 乾燥肌、荒れ肌の指標
• 肌質の違いの指標
• 肌の透明感の指標

角質水分量測定の原理

測定は導電性の高いプローブ①を乾燥して導電性の低い皮膚表面②に軽く押しあてます。この表層(角質層）より下には導電性の高い層（真皮）③があり、この関係はちょうど静電容量（キャパシタンス）を測るコンデンサーのような図式が成り立ちます。本器は導電性の低い表層部分（角質層）の水分量に比例するキャパシタンスを測定し、相対値（ＡＵ）として計算します。プローブに内蔵されるフォースセンサーにより常に一定圧での測定を可能にしています。（これにより測定される角質層の測定時の厚さを一定にすることが可能です。） 

従来型角質水分計との比較

上のグラフは数種類の異なった基礎化粧品、保湿剤を塗布した時の変化を見ています。従来型のキャパシタンス水分計（CM)では一定の傾向が見られ、水分変化が捉えられにくくなっています。一方「MoistureMeter SC Compact」の測定では塗布後の角質内の水分変化を敏感に捉えています。

Ultrathin conformal devices for precise and continuous thermal characterization of human skin Webb R.C., Bonifas A.P., Behnaz A., Zhang Y., Yu K.J., Cheng H., Shi M., Bian Z., Liu Z., Kim Y.S., Yeo W.H., Park J.S., Song J., Li Y., Huang Y., Gorbach A.M. and Rogers J.A.
Nat Mater, Oct;12(10):938-44, 2013.
 
Biophysical measures of skin tissue water: variations within and among anatomical sites and correlations between measures
Mayrovitz H.N., Bernal M., Brlit F. and Desfor R.
Skin Res Technol, 19(1)47-54, 2013.
 
Relationship between the dietary intake of water and skin hydration
Palma M.L., Monteiro C., Tavares L., Bujan M.J. and Rodrigues L.M.
Biomed Biopharm Res, 9(2):173-181, 2012.
 
A phase 2, double-blind, randomized, placebo-controlled trial of a novel nutritional supplement product to promote healthy skin
Dayan S.H., Arkins J.P., Sharma V., Paterson E. and Barnes D.
J Drugs Dernatol, Vol 10(10):1106-1114, 2011.
 
Strontium hexaferrite nanomagnets suspended in a cosmetic preparation: a convenient tool to evaluate the biological effects of surface
magnetism on human skin
Zioni T., Perkas N., Wolfus Y., Soroka Y., Popov I., Oron M., Perelshtein I., Bruckental Y., Brégégère F. M., Ma'or Z., Gedanken A., Yeshurun Y., Neuman R. and Milner Y.
Skin Res Technol, Aug;16(3):316-324, 2010.
 
Effect of itch, scratching and mental stress on autonomic nervous system function in atopic dermatitis
Tran B.W., Papoiu A.D.P., Russoniello C.V., Wang H., Patel T.S., Chan Y.-H. and Yosipovitch G.
Acta Derm Venereol, Jun;90(4),354-361, 2010.
 
5-aminolevulinic acid-based photodynamic intense pulsed light therapy shows better effects in the treatment of skin photoaging in asian skin
Yang G., Xiang L.H. and Gold M.H.
J Clin Aesthet Dermatol, Mar;3(3):40-43, 2010.
 
A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients
Young T.A., Patel T.S., Camacho F., Clark A., Freedman B.I., Kaur M., Fountain J., Williams L.L., Yosipovitch G. and Fleischer A.B. Jr.
J Dermatolog Treat, 20(2):76-81, 2009.
 
Microbiological efficacy and tolerability of a new, non-alcohol-based hand disinfectant
Agthe N., Terho K., Kurvinen T., Routamaa M., Peltonen R., Laitinen K. and Kanerva M.
Infect Control Hosp Epidemiol, Jul;30(7):685-90, 2009.
 
Hydrating effects of moisturizer active compounds incorporated into hydrogels: in vivo assessment and comparison between devices
Silva V.R.L., Schulman M.A., Ferelli C., Gimenis J.M., Ruas G.W., Baby A.R., Velasco M.V.R., Taqueda M.E. and Kaneko T.M.
J Cosmet Dermatol, Mar;8(1):21-9, 2009.
 
Use of static and dynamic methods to assess the efficacy of a moisturizing cream
Rosado C., Lourenço A. and Rodrigues L.M. Revista Lusófona de Ciências e Tecnologias da Saúde, Ano 5, nº1, 2008.
 
Noninvasive transcutaneous sampling of glucose by electroporation
Murthy S.S., Kiran V.S.R., Mathur S.K. and Murthy S.N.
J Diabetes Sci Technol, 2(3):250-254, 2008.
 
The use of an extended ventilation tube as a countermeasure for EVA-associated upper extremity medical issues
Jones J.A., Hoffman R.B., Buckland D.A., Harvey C.M., Bowen C.K., Hudy C.E. Strauss S., Novak J. and Gernhardt M.L.
Acta Astronaut, 63:763-768, 2008.
 
Measurement of hydration in the stratum corneum with the MoistureMeter and comparison with the Corneometer
Alanen E., Nuutinen J., Nicklén K., Lahtinen T. and Mönkkönen J.
Skin Res Technol, 10:32-37, 2004.
 
Dielectric properties of the skin
Lahtinen T., Nuutinen J. and Alanen E.
In: Radio Frequency Radiation Dosimetry, Editors: B. J. Klauenberg and D. Miklavcic. Kluwer Academic Publishers, the Netherlands, 2000.
 
Penetration of electromagnetic fields of open-ended coaxial probe between 1 MHz and 1GHz in dielectric skin measurements
Alanen E., Lahtinen T. and Nuutinen J.
Phys Med Biol, 44(7):N169-176, 1999.
 
Variational formulation of open-ended coaxial line in contact with layered biological medium
Alanen E., Lahtinen T. and Nuutinen J.
IEEE Trans Biomed Eng, 45(10):1241-1248, 1998.
 
Dielectric properties of the skin
Lahtinen T., Nuutinen J. and Alanen E.
Phys Med Biol, 42:1471-1472, 1997.
 
Abstracts
 
Mechanism of injury and countermeasures for EVA associated upper extremity medical issues: Extended Vent Tube Study
Jones J., Hoffman R., Harvey G., Bowen C.K., Hudy C.E., Tuxhorn J., Gernhardt M. and Scheuring R.
Prenestation at 15th International Academy of Astronautics’ “Humans in space” symposium in Beijing, 20-24 May 2007.
 
The moisturization ability of a sodium sulfacetamide (10%)/sulfur (5%) emollient foam
Trumbore M.
J Am Acad Dermatol, February: AB21, 2007.
 
Validation des mesures de TEWL et de hydratation du stratum corneum chez le chien
Grellet A. and Fonaine J.
Congrès AFVAC Bordeaux, 7-9 December, 2006.
 
Water content at skin surface and in whole skin during irritant skin reaction
Miettinen M., Nuutinen J, Lahtinen M.-R. and Lahtinen T.
13th Congress of European Academy of Dermatology and Venereology Meeting, 17-21 November, 2004.
 
Requirements for the conductivity measurements of the MoistureMeter
Alanen E., Nuutinen J. and Nicklén K.
Stratum Corneum IV. 17-19 June 2004: p. 48.
 
Susceptibility to SLS irritation: Effect of a five-day pre-use of two skin care oils studied comparing various techniques and instruments
Rantanen T., Snellman E. and Kostiainen M.
First World Congress on Work-Related and Environmental Allergy. 9-12 July 2003: p. 95.
 
Pressure-controlled measurement of skin surface hydration with MoistureMeter
Nuutinen J., Alanen E. and Nicklén K.
Skin Res Technol, Vol 9(2):202, 2003.
 
Ultrathin conformal devices for precise and continuous thermal characterization of human skin Webb R.C., Bonifas A.P., Behnaz A., Zhang Y., Yu K.J., Cheng H., Shi M., Bian Z., Liu Z., Kim Y.S., Yeo W.H., Park J.S., Song J., Li Y., Huang Y., Gorbach A.M. and Rogers J.A.
Nat Mater, Oct;12(10):938-44, 2013.
 
Biophysical measures of skin tissue water: variations within and among anatomical sites and correlations between measures
Mayrovitz H.N., Bernal M., Brlit F. and Desfor R.
Skin Res Technol, 19(1)47-54, 2013.
 
Relationship between the dietary intake of water and skin hydration
Palma M.L., Monteiro C., Tavares L., Bujan M.J. and Rodrigues L.M.
Biomed Biopharm Res, 9(2):173-181, 2012.
 
A phase 2, double-blind, randomized, placebo-controlled trial of a novel nutritional supplement product to promote healthy skin
Dayan S.H., Arkins J.P., Sharma V., Paterson E. and Barnes D.
J Drugs Dernatol, Vol 10(10):1106-1114, 2011.
 
Strontium hexaferrite nanomagnets suspended in a cosmetic preparation: a convenient tool to evaluate the biological effects of surface
magnetism on human skin
Zioni T., Perkas N., Wolfus Y., Soroka Y., Popov I., Oron M., Perelshtein I., Bruckental Y., Brégégère F. M., Ma'or Z., Gedanken A., Yeshurun Y., Neuman R. and Milner Y.
Skin Res Technol, Aug;16(3):316-324, 2010.
 
Effect of itch, scratching and mental stress on autonomic nervous system function in atopic dermatitis
Tran B.W., Papoiu A.D.P., Russoniello C.V., Wang H., Patel T.S., Chan Y.-H. and Yosipovitch G.
Acta Derm Venereol, Jun;90(4),354-361, 2010.
 
5-aminolevulinic acid-based photodynamic intense pulsed light therapy shows better effects in the treatment of skin photoaging in asian skin
Yang G., Xiang L.H. and Gold M.H.
J Clin Aesthet Dermatol, Mar;3(3):40-43, 2010.
 
A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients
Young T.A., Patel T.S., Camacho F., Clark A., Freedman B.I., Kaur M., Fountain J., Williams L.L., Yosipovitch G. and Fleischer A.B. Jr.
J Dermatolog Treat, 20(2):76-81, 2009.
 
Microbiological efficacy and tolerability of a new, non-alcohol-based hand disinfectant
Agthe N., Terho K., Kurvinen T., Routamaa M., Peltonen R., Laitinen K. and Kanerva M.
Infect Control Hosp Epidemiol, Jul;30(7):685-90, 2009.
 
Hydrating effects of moisturizer active compounds incorporated into hydrogels: in vivo assessment and comparison between devices
Silva V.R.L., Schulman M.A., Ferelli C., Gimenis J.M., Ruas G.W., Baby A.R., Velasco M.V.R., Taqueda M.E. and Kaneko T.M.
J Cosmet Dermatol, Mar;8(1):21-9, 2009.
 
Use of static and dynamic methods to assess the efficacy of a moisturizing cream
Rosado C., Lourenço A. and Rodrigues L.M. Revista Lusófona de Ciências e Tecnologias da Saúde, Ano 5, nº1, 2008.
 
Noninvasive transcutaneous sampling of glucose by electroporation
Murthy S.S., Kiran V.S.R., Mathur S.K. and Murthy S.N.
J Diabetes Sci Technol, 2(3):250-254, 2008.
 
The use of an extended ventilation tube as a countermeasure for EVA-associated upper extremity medical issues
Jones J.A., Hoffman R.B., Buckland D.A., Harvey C.M., Bowen C.K., Hudy C.E. Strauss S., Novak J. and Gernhardt M.L.
Acta Astronaut, 63:763-768, 2008.
 
Measurement of hydration in the stratum corneum with the MoistureMeter and comparison with the Corneometer
Alanen E., Nuutinen J., Nicklén K., Lahtinen T. and Mönkkönen J.
Skin Res Technol, 10:32-37, 2004.
 
Dielectric properties of the skin
Lahtinen T., Nuutinen J. and Alanen E.
In: Radio Frequency Radiation Dosimetry, Editors: B. J. Klauenberg and D. Miklavcic. Kluwer Academic Publishers, the Netherlands, 2000.
 
Penetration of electromagnetic fields of open-ended coaxial probe between 1 MHz and 1GHz in dielectric skin measurements
Alanen E., Lahtinen T. and Nuutinen J.
Phys Med Biol, 44(7):N169-176, 1999.
 
Variational formulation of open-ended coaxial line in contact with layered biological medium
Alanen E., Lahtinen T. and Nuutinen J.
IEEE Trans Biomed Eng, 45(10):1241-1248, 1998.
 
Dielectric properties of the skin
Lahtinen T., Nuutinen J. and Alanen E.
Phys Med Biol, 42:1471-1472, 1997.
 
Abstracts
 
Mechanism of injury and countermeasures for EVA associated upper extremity medical issues: Extended Vent Tube Study
Jones J., Hoffman R., Harvey G., Bowen C.K., Hudy C.E., Tuxhorn J., Gernhardt M. and Scheuring R.
Prenestation at 15th International Academy of Astronautics’ “Humans in space” symposium in Beijing, 20-24 May 2007.
 
The moisturization ability of a sodium sulfacetamide (10%)/sulfur (5%) emollient foam
Trumbore M.
J Am Acad Dermatol, February: AB21, 2007.
 
Validation des mesures de TEWL et de hydratation du stratum corneum chez le chien
Grellet A. and Fonaine J.
Congrès AFVAC Bordeaux, 7-9 December, 2006.
 
Water content at skin surface and in whole skin during irritant skin reaction
Miettinen M., Nuutinen J, Lahtinen M.-R. and Lahtinen T.
13th Congress of European Academy of Dermatology and Venereology Meeting, 17-21 November, 2004.
 
Requirements for the conductivity measurements of the MoistureMeter
Alanen E., Nuutinen J. and Nicklén K.
Stratum Corneum IV. 17-19 June 2004: p. 48.
 
Susceptibility to SLS irritation: Effect of a five-day pre-use of two skin care oils studied comparing various techniques and instruments
Rantanen T., Snellman E. and Kostiainen M.
First World Congress on Work-Related and Environmental Allergy. 9-12 July 2003: p. 95.
 
Pressure-controlled measurement of skin surface hydration with MoistureMeter
Nuutinen J., Alanen E. and Nicklén K.
Skin Res Technol, Vol 9(2):202, 2003.